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Rosemary Supreme

Price: $25.95
Rosemary Supreme™ is packaged in a bottle containing 120 veggie capsules, each containing approximately 330 mg of Rosmarinus officinalis. No fillers, binders, or excipients.

Rosemary Supreme™  was developed as a collaboration between Dr. Walter Schmitt and Dr. Michael Lebowitz. As with other Supreme Nutrition products it took a while to source a raw material that consistently tested good as well as performed clinically. This will distinguish it quality-wise from the common kitchen rosemary (though it is the same plant) as well as other brands of capsules that have stearic acid or rice powder added and didn’t go through kinesiological quality control testing. Our source is also organically grown.

Rosemary’s main therapeutic properties are that it is 1. A powerful antioxidant with immune modulating properties and 2. It possesses extrahepatic estrogen breakdown effects 3. May enhance cognitive ability as we age.

Rosemary contains three antioxidant substances that have potentially beneficial properties for our health: rosmarinic acid, carnosic acid, and ursolic acid.

Rosmarinic acid

Rosmarinic acid impacts estrogen breakdown in a positive way. Estradiol and estrone are detoxified via pathways that can be protective or carcinogenic, especially to tissues such as the breast and prostate. Rosmarinic acid has been shown to direct the metabolism of these estrogens toward the protective 2-hydroxy estrone pathway and away from the carcinogenic 4-hydroxy estrone and 16-hydroxy estrone pathways. Any female or male patient with personal or family history of estrogen driven cancers should be evaluated for rosemary.
(ref: B T Zhu, D P Loder, M X Cai, C T Ho, M T Huang and A H Conney, Dietary administration of an extract from rosemary leaves enhances the liver microsomal metabolism of endogenous estrogens and decreases their uterotropic action in CD-1 mice. Carcinogenesis. 1998 Oct;19(10):1821-7.)

Rosmarinic acid also has important antioxidant effects. In the arachidonic acid cascade it shifts the production of the highly inflammatory leukotriene B4 toward the production of prostaglandin E2. It also inhibits the complement system, the inflammatory activity driven by the innate immune system.
In mice, it has been shown to inhibit the allergic airway inflammation induced by house dust mites in vivo. (Ref: Inoue K et al, Effects of volatile constituents of a rosemary extract on allergic airway inflammation related to house dust mite allergen in mice. Int J Mol Med. 2005 Aug;16(2):315-9.)

Carnosic acid

Carnosic acid, and its metabolite carnosol also have antioxidant properties including neuroprotective effects in the brain. (Ref: Satoh T, Kosaka K, Itoh K, Kobayashi A, Yamamoto M, Shimojo Y, Kitajima C, Cui J, Kamins J, Okamoto SI, Izumi M, Shirasawa T, Lipton SA. Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1. J Neurochem. 2008 Feb;104(4):1116-31. Epub 2007 Nov 6. ) These effects include increasing reduced glutathione and protecting against middle cerebral artery ischemia/reperfusion.

Carnosol has been shown to inhibit lipopolysaccharide (LPS) and interferon-ã (IFNã) induced nitrite production by mouse peritoneal cells by more than 50%. Nitric oxide and the further production of peroxynitrate and nitrite have DNA damaging and carcinogenic effects. (Ref: Marion Man-Ying Chan, Chi-Tang Hoc and Hsing-I Huang, Effects of thre dietary phytochemicals frm tea, rosemary, and turmeric on inflammation-induced nitrite production. Cancer Letters, Vol 96, Issue 1, 4 September 1995, pages 23-29.)

Carnosol performs this antioxidant activity by decreasing nitric oxide production via inhibition of inducible nitric oxide synthase (iNOS) and nuclear factor kappa-B (NF-êB) promoter activity. These activities provide possible mechanisms for its anti-inflammatory and chemopreventive action.

(Ref: Ai-Hsiang Lo, Yu-Chih Liang, Shoei-Yn Lin-Shiau, Chi-Tang Ho and Jen-Kun Lin, Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-êB in mouse macrophages. Carcinogenesis Volume 23, Issue 6 Pp. 983-991)

Ursolic Acid

Ursolic acid has been found to reduce muscle atrophy and to stimulate muscle growth in mice. Ursolic acid has potential use as a cardioprotective compound.

So to sum up - rosemary should be thought of as a product to help estrogen degradation, as a powerful antioxidant, and as a cardioprotective and neuroprotective agent as well as in many autoimmune disorders.

For those of you that use Dr Schmitt’s protocols the following are AK indicators that may need Rosemary Supreme:
1) Weakness induced by homeopathic 4-OH estrone or 16-OH estrone negated by rosemary.
2) Weakness induced by homeopathic inflammatory cytokines (especially TNF-alpha and interferon-gamma) negated by rosemary.

Test rosemary in any free radical / inflammatory disease (including autoimmunity) patient, including those who might weaken on bleach sniff, or hydrogen peroxide sniff, either by testing a muscle that is weak in the clear or by observing for rosemary negating the challenge weakness.

For those of you who utilize Dr. Lebowitz protocols see if a weakening of any of the 3 of the estrogen vials in the biochemical/hormone kit are negated by Rosemary. It may also negate the weakening of any of the chemical composites (industrial and environmental 1 and 3, chemical and inhalant, pesticides 1,2, and 3, dental, food additives, etc.) Also strengthening in the clear would be an indicator.

Dose is 1-2 caps daily 2-3x/day.

Warning: Rosemary may affect the blood's ability to clot, and could interfere with any blood-thinning drugs you are taking. Be sure to consult your doctor if you are taking Plavix, Coumadin, or Aspirin or any other type of blood thinner.

Rosemary may interfere with the action of ACE inhibitors in high blood pressure medications like: Monopril, Vasotec, Zestril, Capoten or any other such medications.

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